Annie Runes explained
There's one set of runes for Annie on patch 14.12 that is the clear favorite for LoL players and pros alike. The best Annie rune paths on the position 
Mid are 
Inspiration as the primary path and 
Sorcery as the secondary path with a pick rate of 79%. Besides picking runes on Annie you should learn how to play Annie and if you are interested in pro matches take a look on how a pro builds Annie. If you want to discuss 
Annie then you should visit the champion subreddit.
Annie runes from primary path
Inspiration opens creative opportunities on Annie troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that First Strike is the best keystone rune to run on Annie. Other primary runes on Annie are Cash Back, Biscuit Delivery and Cosmic Insight.
You can enter debt to buy items, which is displayed as negative gold in your inventary. A small lending fee is added onto the amount of gold you owe after leaving the shop. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Cosmic Insight grants summoner spell and item haste.
Annie runes from secondary path
When it comes to your secondary path, most Annie players prefer to go with Sorcery. Sorcery empoweres abilities of Annie and increases the available champion resources. On the Sorcery path, the best runes for Annie are 
Manaflow Band and 
Scorch.
This is usually followed up by taking Manaflow Band for additional mana and mana regenaration. Scorch increases your control in the early game.
FAQ for Annie Runes
Which is the best keystone rune on Annie?
The best keystone rune on Annie is First Strike. This Annie runes setup is then referred as Annie First Strike.
What runes does Annie use?
Runes from the paths Inspiration and Sorcery are the most used runes on Annie. For the exact pick rates of Annie runes used, you have to study the rune distribution presented.