Gangplank Runes explained
There's one set of runes for Gangplank on patch 14.10 that is the clear favorite for LoL players and pros alike. The best Gangplank rune paths on the position 
Top are 
Inspiration as the primary path and 
Sorcery as the secondary path with a pick rate of 36%. Besides picking runes on Gangplank you should learn how to play Gangplank and if you are interested in pro matches take a look on how a pro builds Gangplank. If you want to discuss 
Gangplank then you should visit the champion subreddit.
Gangplank runes from primary path
Inspiration opens creative opportunities on Gangplank troughout the match. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
First Strike is the best keystone rune to run on Gangplank. Other primary runes on Gangplank are 
Cash Back, 
Biscuit Delivery and 
Cosmic Insight.
You can enter debt to buy items, which is displayed as negative gold in your inventary. A small lending fee is added onto the amount of gold you owe after leaving the shop. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes. Cosmic Insight grants summoner spell and item haste.
Gangplank runes from secondary path
When it comes to your secondary path, most Gangplank players prefer to go with Sorcery. Sorcery empoweres abilities of Gangplank and increases the available champion resources. On the Sorcery path, the best runes for Gangplank are 
Gathering Storm and 
Transcendence.
Gathering Storm increases your late game power. Transcendence for some more Ability Haste.
FAQ for Gangplank Runes
Which is the best keystone rune on Gangplank?
The best keystone rune on Gangplank is First Strike. This Gangplank runes setup is then referred as Gangplank First Strike.
What runes does Gangplank use?
Runes from the paths Inspiration and Sorcery are the most used runes on Gangplank. For the exact pick rates of Gangplank runes used, you have to study the rune distribution presented.