Kayn Runes explained
There's one set of runes for Kayn on patch 14.24 that is the clear favorite for LoL players and pros alike. The best Kayn rune paths on the position 
Jungle are 
Domination as the primary path and 
Inspiration as the secondary path with a pick rate of 38%. Besides picking runes on Kayn you should learn how to play Kayn and if you are interested in pro matches take a look on how a pro builds Kayn. If you want to discuss 
Kayn then you should visit the champion subreddit.
Kayn runes from primary path
Domination improves burst damage and assassination tools on Kayn. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Conqueror is the best keystone rune to run on Kayn. This keystone rune provides additional power in the later stages of a game. As soon as Conqueror is fully charged, Kayn deals additional damage and gains life steal. Other primary runes on Kayn are Sudden Impact, Eyeball Collection and Treasure Hunter.
Sudden Impact increases your damage after dashing or being invisible. This is due to how easy it is to activate on Kayn with the amount of ways he has to dash, jump or going invisible. The additional lethality helps to take down the priority targets that much easier. Eyeball Collection is next up. This grants the user additional damage with every killing they score. Treasure Hunter is the final rune of the Domination path. This rune gives Kayn additional gold for takedowns. The additional gold is nothing to scoff at and can mean the difference between winning or losing a battle. Kayn will gain an additional 70 gold for the first takedown. Kayn acquires Bounty Hunter Stacks, which Kayn may use to get more takedowns. This rune's power will grow tremendously, and Kayn will become wealthy like never been before. Each time a fresh stack of Bounty Hunter Stacks is consumed, Kayn will get an additional twenty gold.
Kayn runes from secondary path
When it comes to your secondary path, most Kayn players prefer to go with Inspiration. Inspiration opens creative opportunities on Kayn troughout the match. On the Inspiration path, the best runes for Kayn are 
Cosmic Insight and 
Magical Footwear.
Cosmic Insight grants summoner spell and item haste. Magical Footwear allows Kayn to focus on those essential core items without the need to spend the additional 300 gold on boots.
FAQ for Kayn Runes
Which is the best keystone rune on Kayn?
The best keystone rune on Kayn is Conqueror. This Kayn runes setup is then referred as Kayn Conqueror.
What runes does Kayn use?
Runes from the paths Domination and Inspiration are the most used runes on Kayn. For the exact pick rates of Kayn runes used, you have to study the rune distribution presented.