Nasus Runes explained
There's one set of runes for Nasus on patch 15.13 that is the clear favorite for LoL players and pros alike. The best Nasus rune paths on the position 
Top are 
Resolve as the primary path and 
Inspiration as the secondary path with a pick rate of 30%. Besides picking runes on Nasus you should learn how to play Nasus and if you are interested in pro matches take a look on how a pro builds Nasus. If you want to discuss 
Nasus then you should visit the champion subreddit.
Nasus runes from primary path
Resolve empowers the survivability of Nasus and increases the tankiness. Most of high elo players – and our LoL pros in the the major regions – have agreed that Grasp of the Undying is the best keystone rune to run on Nasus. This keystone rune gives Nasus alot of sustain and helps to force your opposing champion out of the lane. Other primary runes on Nasus are Demolish, Second Wind and Unflinching.
Demolish increases your pressure on the enemy turrets. This rune will help you to punish bad roams or backtimings of your lane opponent. Second Wind powers up your sustainablity in lane by healing after taking damage from an enemy champion. Unflinching inceases Nasus tenacity based on your missing health.
Nasus runes from secondary path
When it comes to your secondary path, most Nasus players prefer to go with Inspiration. Inspiration opens creative opportunities on Nasus troughout the match. On the Inspiration path, the best runes for Nasus are 
Approach Velocity and 
Biscuit Delivery.
Nasus gains bonus movement speed by Approach Velocity, while moving toward enemy champions that are immobilized or slowed. This rune is perfect to follow up engages by your teammates. Biscuit Delivery is a great rune for laning as it gives additional health and mana, which can help in more aggressive lanes.
FAQ for Nasus Runes
Which is the best keystone rune on Nasus?
The best keystone rune on Nasus is Grasp of the Undying. This Nasus runes setup is then referred as Nasus Grasp of the Undying.
What runes does Nasus use?
Runes from the paths Resolve and Inspiration are the most used runes on Nasus. For the exact pick rates of Nasus runes used, you have to study the rune distribution presented.