Nunu & Willump Runes explained
There's one set of runes for Nunu & Willump on patch 15.2 that is the clear favorite for LoL players and pros alike. The best Nunu & Willump rune paths on the position 
Jungle are 
Sorcery as the primary path and 
Domination as the secondary path with a pick rate of 49%. Besides picking runes on Nunu & Willump you should learn how to play Nunu & Willump and if you are interested in pro matches take a look on how a pro builds Nunu & Willump. If you want to discuss 
Nunu & Willump then you should visit the champion subreddit.
Nunu & Willump runes from primary path
Sorcery empoweres abilities of Nunu & Willump and increases the available champion resources. Most of high elo players – and our LoL pros in the the major regions – have agreed that 
Phase Rush is the best keystone rune to run on Nunu & Willump. Phase Rush offers more flexibility and options to betake oneself in and out of danger, which can be helpful since that's essentially the main playstyle of Nunu & Willump. Other primary runes on Nunu & Willump are 
Nimbus Cloak, 
Celerity and 
Waterwalking.
Nimbus Cloak, which grants movement speed upon using a summoner spell, works amazingly well with junglers in particular as they take the shortest cooldown summoner spell, Smite. Celerity boosts all movement speed bonuses to Nunu & Willump. Waterwalking grants movement speed in the river, which helps Nunu & Willump get around the map quicker. The extra damage will also help in those all important dragon and baron fights.
Nunu & Willump runes from secondary path
When it comes to your secondary path, most Nunu & Willump players prefer to go with Domination. Domination improves burst damage and assassination tools on Nunu & Willump. On the Domination path, the best runes for Nunu are Cheap Shot and Relentless Hunter.
Cheap Shot makes you deal more damage to enemies with impaired movement, which has great synergy with the setup of Nunu & Willump. Relentless Hunter increases your movement speed out of combat due to every unique champion takedown.
FAQ for Nunu & Willump Runes
Which is the best keystone rune on Nunu & Willump?
The best keystone rune on Nunu & Willump is Phase Rush. This Nunu & Willump runes setup is then referred as Nunu & Willump Phase Rush.
What runes does Nunu & Willump use?
Runes from the paths Sorcery and Domination are the most used runes on Nunu & Willump. For the exact pick rates of Nunu & Willump runes used, you have to study the rune distribution presented.